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Our goal,
working with many other scientists against cancer, is to understand normal cell
processes that go wrong in tumors. Our group uses model systems in which these
processes can be more easily studied than in tumors. One of these models has
been, for many years, cell differentiation during spermatogenesis. We have
characterized changes in chromatin composition and structure and changes in gene
expression during the differentiation of the male gamete. We are now mainly
interested in the study of the processes of cell death and survival during
testicular development and regression. Formation of new vessels, angiogenesis,
and vascular regression are crucial for these phenomena and could help us to
understand key mechanisms involved in tumor development and
metastasis.
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